Defitelio
Named-patient access overview. Defitelio is coordinated by Reserve Meds for international patients through cross-border sourcing coordinated with your treating doctor.
Ask about Defitelio
Tell us the medicine and your country. We reply within one business day. On WhatsApp we usually reply the same day.
Quick orientation
Defitelio (defibrotide sodium) is a polydeoxyribonucleotide endothelial-protective agent developed by Jazz Pharmaceuticals. The US Food and Drug Administration approved Defitelio in March 2016 for the treatment of adult and paediatric patients with hepatic veno-occlusive disease (also called sinusoidal obstruction syndrome) with renal or pulmonary dysfunction following haematopoietic stem-cell transplantation (HSCT). Defitelio is administered as a 6.25 mg/kg intravenous infusion every 6 hours over 2 hours, for a minimum of 21 days and continued until VOD/SOS resolution. The drug is delivered in the inpatient HSCT centre under transplant haematology supervision.
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How Reserve Meds coordinates Defitelio
- Patient or treating physician submits an intake at the patient portal.
- Reserve Meds clinical team verifies appropriateness for the patient and destination country.
- Treating physician issues prescription and clinical justification.
- Country-specific named-patient documentation is prepared.
- Defitelio is sourced from a US-licensed pharmaceutical wholesale partner with full serial traceability.
- Shipment is coordinated to the patient's physician or hospital pharmacy with appropriate handling.
Clinical trials and expanded access
On 17 October 2026 we searched ClinicalTrials.gov, the clinical study registry of the US National Library of Medicine, for studies that list defibrotide as an intervention. The search found studies that are recruiting or not yet recruiting. See the current list on ClinicalTrials.gov.
Whether a patient can join a trial or an expanded access program is decided by the study team or the manufacturer, together with the treating doctor. Reserve Meds does not run trials or supply investigational medicines. We can help you and your doctor read a listing and understand the route.
Access by country
Reserve Meds publishes a detailed country access guide for Defitelio in every market we coordinate. Each page below covers the destination-country regulatory pathway, how quotes work, indicative timelines, physician-credential requirements, and handling notes. Tap any country to read the full deep-dive.
Start a request for Defitelio
Submit a 60-second intake. We reply within one business day with case-specific feasibility, timeline, and a formal quote.
Frequently asked questions
How can I get Defitelio if it is not approved or available in my country?
Reserve Meds coordinates US-sourced Defitelio for patients through a legal named-patient pathway, working with your treating doctor. Your treating physician provides the prescription and clinical justification; Reserve Meds prepares the named-patient documentation for your country and arranges DSCSA-compliant US sourcing and delivery to your physician or hospital pharmacy.
Can I access Defitelio through a named-patient import?
Often, yes. Named-patient access (sometimes called personal import) is the legal route we use for FDA-approved medicines such as Defitelio. It is different from compassionate use, which covers investigational medicines through the manufacturer's own program; we do not supply investigational medicines. Eligibility and paperwork depend on the regulator in your country, and Reserve Meds maps the specific pathway for each market it coordinates.
Do I need a prescription to access Defitelio through Reserve Meds?
Yes. Reserve Meds is not a pharmacy and does not prescribe. A valid prescription and clinical justification from your treating physician are required, and all clinical decisions remain with your physician.
How does Reserve Meds deliver Defitelio to a patient?
Medicines are supplied through a US-licensed pharmaceutical wholesale partner, and Reserve Meds coordinates delivery of Defitelio to your treating physician or hospital pharmacy, with appropriate handling for the product.
How long does it take, and what does Defitelio cost through Reserve Meds?
After a short intake, the clinical team responds within one business day with case-specific feasibility, an indicative timeline, and a formal written quote. Cost depends on the destination, the prescribed regimen, and the duration of therapy, and is confirmed in writing before anything proceeds.
How do I start a request for Defitelio?
Submit a 60-second intake through the Reserve Meds patient portal, or message our team on WhatsApp. We reply within one business day. On WhatsApp we usually reply the same day.