Voyxact (sibeprenlimab-szsi, anti-APRIL mAb for IgA nephropathy)
Named-patient access overview. Voyxact is coordinated by Reserve Meds for international patients through cross-border sourcing coordinated with your treating doctor.
Ask about Voyxact
Tell us the medicine and your country. We reply within one business day. On WhatsApp we usually reply the same day.
About Voyxact
Voyxact (sibeprenlimab-szsi) is a humanized IgG2 monoclonal antibody developed by Otsuka Pharmaceutical (originated at Visterra) for adults with primary IgA nephropathy at risk of disease progression. Sibeprenlimab binds and neutralizes APRIL (A PRoliferation-Inducing Ligand, also known as TNFSF13), a B-cell and plasma-cell cytokine that drives the production of pathogenic galactose-deficient IgA1, the immunoglobulin species at the root of IgA nephropathy.
Voyxact is administered by subcutaneous injection. By targeting the upstream APRIL axis on B cells and plasma cells, it works at a different point in the disease pathway than the available alternatives: sparsentan (RAAS and endothelin receptor blockade), iptacopan (alternative-pathway complement), and gut-targeted budesonide (Tarpeyo). Approval pathway, exact eGFR and proteinuria cutoffs, and full label population should be confirmed against the current FDA label for sibeprenlimab-szsi before prescribing.
For international patients, Voyxact is sourced by Reserve Meds from a US-licensed pharmaceutical wholesale partner with full serial traceability and may be accessible via Named Patient Program or personal-import pathways depending on destination country.
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How Reserve Meds coordinates Voyxact
- Patient or treating physician submits a named-patient request.
- Clinical team verifies appropriateness of Voyxact for the patient and destination country.
- Treating physician issues prescription and clinical justification.
- Country-specific NPP / personal-import documentation is prepared.
- Voyxact is sourced from a US-licensed pharmaceutical wholesale partner with full serial traceability.
- Shipment is coordinated to the patient's physician or hospital pharmacy (cold-chain where required).
Clinical trials and expanded access
On 17 October 2026 we searched ClinicalTrials.gov, the clinical study registry of the US National Library of Medicine, for studies that list sibeprenlimab as an intervention. The search found studies that are recruiting or not yet recruiting. See the current list on ClinicalTrials.gov.
Whether a patient can join a trial or an expanded access program is decided by the study team or the manufacturer, together with the treating doctor. Reserve Meds does not run trials or supply investigational medicines. We can help you and your doctor read a listing and understand the route.
Start a request for Voyxact
Send us the medicine and your country. We reply within one business day with case-specific feasibility, timeline, and a formal quote.
Frequently asked questions
How can I get Voyxact if it is not approved or available in my country?
Reserve Meds coordinates US-sourced Voyxact for patients through a legal named-patient pathway, working with your treating doctor. Your treating physician provides the prescription and clinical justification; Reserve Meds prepares the named-patient documentation for your country and arranges DSCSA-compliant US sourcing and delivery to your physician or hospital pharmacy.
Can I access Voyxact through a named-patient import?
Often, yes. Named-patient access (sometimes called personal import) is the legal route we use for FDA-approved medicines such as Voyxact. It is different from compassionate use, which covers investigational medicines through the manufacturer's own program; we do not supply investigational medicines. Eligibility and paperwork depend on the regulator in your country, and Reserve Meds maps the specific pathway for each market it coordinates.
Do I need a prescription to access Voyxact through Reserve Meds?
Yes. Reserve Meds is not a pharmacy and does not prescribe. A valid prescription and clinical justification from your treating physician are required, and all clinical decisions remain with your physician.
How does Reserve Meds deliver Voyxact to a patient?
Medicines are supplied through a US-licensed pharmaceutical wholesale partner, and Reserve Meds coordinates delivery of Voyxact to your treating physician or hospital pharmacy, with appropriate handling for the product.
How long does it take, and what does Voyxact cost through Reserve Meds?
After a short intake, the clinical team responds within one business day with case-specific feasibility, an indicative timeline, and a formal written quote. Cost depends on the destination, the prescribed regimen, and the duration of therapy, and is confirmed in writing before anything proceeds.
How do I start a request for Voyxact?
Submit a 60-second intake through the Reserve Meds patient portal, or message our team on WhatsApp. We reply within one business day. On WhatsApp we usually reply the same day.