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MASH, metabolic dysfunction-associated steatohepatitis (formerly NASH): US-approved treatments and how Gulf families can access them

Creator: Reserve Meds
Published: 2026-10-17

A plain guide for families in the Gulf, checked against US FDA labels, Gulf drug registers and published medical research.

Reviewed by the Reserve Meds clinical operations team on 17 October 2026.

MASH (formerly NASH): the short answer

The US FDA has approved two medicines on this page for MASH (formerly NASH), each for specific patients. Two of them are on at least one Gulf register we checked, so ask your hospital about local supply first. Otherwise the hospital can request a named-patient import. Reserve Meds is a digital health company. We do not diagnose or prescribe.

US FDA-approved medicines on this page: Rezdiffra and Wegovy.
Gulf registration (checked 17 October 2026): see each medicine below.
Legal route: Local supply where listed; otherwise a named-patient import request filed by the treating hospital.
Price: Quote on request.

What is MASH (formerly NASH)?

Steatotic liver disease, formerly called fatty liver disease, happens when too much fat builds up in the liver. When it is not caused by heavy alcohol use, it is called metabolic dysfunction-associated steatotic liver disease (MASLD), previously nonalcoholic fatty liver disease.^[1]

MASH, metabolic dysfunction-associated steatohepatitis (previously NASH), is the more serious form. Besides fat, there is inflammation and liver damage, which can lead to scarring (fibrosis). Over time, scarring can lead to cirrhosis or liver cancer.^[1]

Treatment starts with diet, exercise and managing related conditions such as diabetes and obesity. In the US, two medicines are approved for adults with MASH who have moderate to advanced fibrosis (stages F2 to F3) without cirrhosis, both under accelerated approval.^{[2, 3]}

MASH (formerly NASH) in the Gulf

Using Global Burden of Disease data for 21 Middle East and North Africa countries, researchers estimated that MASLD prevalence rose from 26.3% to 27.7% between 2010 and 2021, while adult obesity rose from 25.4% to 31.3% and adult diabetes from 7.4% to 12.1%.^[4]

US FDA-approved medicines for MASH (formerly NASH)

Each medicine below is approved in the US for a specific group of patients. The wording summarizes the current US label. Your specialist decides whether any of them is right for the patient.

Rezdiffra (resmetirom)
FDA-approved for adults with noncirrhotic MASH with moderate to advanced liver fibrosis (stages F2 to F3), together with diet and exercise. It is a tablet taken once a day. Approved under accelerated approval.^[2]
Gulf registers: Saudi Arabia: not found by brand name in the SFDA drugs list. Abu Dhabi: has an active code in the Abu Dhabi DoH drug code list. Checked 17 October 2026. UAE federal status, Kuwait, Qatar, Bahrain and Oman: not verified in a public register.^{[5, 6]}
Country guides: Saudi Arabia, UAE, Kuwait, Qatar, Bahrain, Oman, Egypt, India, Pakistan
Wegovy (semaglutide)
FDA-approved for adults with noncirrhotic MASH with moderate to advanced liver fibrosis (stages F2 to F3), under accelerated approval. It is a weekly injection, also approved for weight management and to lower cardiovascular risk.^[3]
Gulf registers: Saudi Arabia: listed in the SFDA drugs list. Abu Dhabi: has an active code in the Abu Dhabi DoH drug code list. Checked 17 October 2026. UAE federal status, Kuwait, Qatar, Bahrain and Oman: not verified in a public register.^{[5, 6]}
Country guides: Saudi Arabia, UAE, Kuwait, Qatar, Bahrain, Oman, Egypt, Turkey, India, Pakistan

How families in the Gulf can access these medicines

If the medicine is listed in your country. Ask your specialist and the hospital pharmacy about local supply first. A listing does not mean every hospital stocks the medicine, and another brand of the same medicine may also be registered, but local supply is usually the fastest route and you may not need us.

If it is not registered. The usual legal route is a named-patient request: the treating hospital, on your specialist's written request, asks the national regulator for permission to import the medicine for one patient, using the US FDA approval as the reference. In Saudi Arabia the SFDA Special Access Program guidance covers these requests; in Bahrain, NHRA Circular 41 of 2020 sets the procedure. Other Gulf countries have their own procedures, which the hospital pharmacy confirms.^{[7, 8]} Once approval is in place, Reserve Meds arranges supply through a US-licensed pharmaceutical wholesale partner to the hospital pharmacy.

Who does what

Your treating specialist decides whether a medicine is right for the patient and writes the letter.
The hospital checks local supply, files any import request, and gives the treatment safely.
The national regulator decides whether to approve the import of a medicine that is not registered.
The manufacturer decides where its medicine can be supplied, especially for cell and gene therapies.
Reserve Meds helps organize records, coordinates US supply through our wholesale partner, shipping and updates to your family. We do not give medical advice.

Documents you will usually need

A letter from the treating specialist with the diagnosis, past treatments and why the medicine is being considered
Reports that confirm the diagnosis, such as laboratory, genetic, imaging or pathology results, translated into English where needed
Recent clinic notes and a list of current medicines
For a hospital import request: the prescription, the hospital's request form and the written consent of the patient or guardian
Proof of the US FDA approval and the US prescribing information (we can supply these)

We give you a written timeline estimate once we see the hospital file. The regulator, the treatment center and the manufacturer set their own timelines.

What treatment costs

Quote on request. Your total cost depends on the medicine, the dose, shipping, import steps and coordination. Your coordination fee is quoted in writing for your case before you commit. No hidden charges.

How Reserve Meds helps

Reserve Meds is a digital health company. Medicines are supplied through a US-licensed pharmaceutical wholesale partner. We help your doctor and hospital prepare the file, arrange US supply and temperature-controlled shipping once approval is in place, and keep your family updated. We coordinate access to FDA-approved medicines only. Investigational medicines are only available through a manufacturer's expanded-access program requested by the treating physician; we can explain that route, but we do not supply them.

Ask us about treatment for MASH (formerly NASH)

Tell us the medicine, your country and a WhatsApp or phone number. We reply within one business day. On WhatsApp we usually reply the same day.

Frequently asked questions

Is there an FDA-approved treatment for MASH (formerly NASH)?

Yes. The medicines on this page have US FDA approval for specific groups of patients: Rezdiffra and Wegovy. The exact conditions are in each US label and are summarized above. Your specialist decides whether any of them fits.

Is Rezdiffra available in Saudi Arabia or the UAE?

Saudi Arabia: not found by brand name in the SFDA drugs list. Abu Dhabi: has an active code in the Abu Dhabi DoH drug code list. Checked 17 October 2026. UAE federal status, Kuwait, Qatar, Bahrain and Oman: not verified in a public register. A listing in Abu Dhabi does not show federal UAE status.

How can a family in the Gulf get Rezdiffra?

Ask the treating hospital about local supply first. If it is not available, the hospital can file a named-patient import request with the national regulator on your specialist's written request. Once approved, we arrange US supply to the hospital pharmacy.

How much does treatment cost?

Quote on request. Your total cost, including the medicine, shipping, import steps and coordination, is quoted in writing for your case before you commit. No hidden charges.

What does F2 to F3 fibrosis mean?

It describes moderate to advanced liver scarring without cirrhosis. Both US labels on this page cover adults in this range. Your hepatologist confirms the stage with tests.

Is MASH the same as NASH?

Yes. MASH is the newer name for what was called nonalcoholic steatohepatitis (NASH).

Sources for the last two answers: ^{[2, 3]} ^[1]

Sources

Checked on 17 October 2026. Labels, registers and regulator rules change. Your hospital pharmacy confirms the current position before filing.

This page is general health information, not medical advice. It does not replace a consultation with your doctor.